Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain: isoflurane or ischemia-reperfusion?
نویسندگان
چکیده
1. Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW: Isofluraneinduced neuroapoptosis in the neonatal rhesus macaque brain. ANESTHESIOLOGY 2010; 112:834 – 41 2. Creeley CE, Olney JW: The young: Neuroapoptosis induced by anesthetics and what to do about it. Anesth Analg 2010; 110:442– 8 3. Hansen TG, Danish Registry Study Group, Flick R, Mayo Clinic Pediatric Anesthesia and Learning Disabilities Study Group: Anesthetic effects on the developing brain: Insights from epidemiology. ANESTHESIOLOGY 2009; 110:1–3
منابع مشابه
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.
BACKGROUND Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent brain, but susceptibility of non-human primates to the apoptogenic action of isoflurane has not been studied. Therefore, we exposed postnatal day 6 (P6) rhesus macaques to a surgical plane of isoflurane anesthesia for 5 h, and studied the brains 3 h later for histopathologic changes. METHOD With the same in...
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BACKGROUND Exposure of the fetal or neonatal non-human primate (NHP) brain to isoflurane or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure to isoflurane also causes apoptotic degeneration of oligodendrocytes (OLs). The present study explored the apoptogenic potential of propofol in the fetal and neonatal NHP brain. METHOD Fetal rhesus macaques at gestation...
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Prolonged exposure to volatile anesthetics, such as isoflurane and sevoflurane, causes neurodegeneration in the developing animal brains. Recent studies showed that dexmedetomidine, a selective α2-adrenergic agonist, reduced isoflurane-induced cognitive impairment and neuroapoptosis. However, the mechanisms for the effect are not completely clear. Thus, we investigated whether exposure to isofl...
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1. Slikker W Jr, Zou X, Hotchkiss CE, et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 2007; 98:145-58. 2. Brambrink AM, Evers AS, Avidan MS, et al. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010;112:834-41. 3. Paule MG, Li M, Allen RR, et al. Ketamine anesthesia during the first week of life can cause long-last...
متن کاملKetamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.
BACKGROUND Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the minimum exposure required for and the extent and spatial distribution of ketamine-induced neuroapoptosis in rhesus fetuses and neonates. METHOD Ketamine was administered by IV infusion for 5 h to postnatal day 6 rhesus...
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ورودعنوان ژورنال:
- Anesthesiology
دوره 113 5 شماره
صفحات -
تاریخ انتشار 2010